近日，福州理工学院应用科学与工程学院青年教师李兢思在International Journal of Biological Macromolecules（SCI中科院/JCR一区TOP期刊，影响因子：8.025）发表了题为《Biomimetic multifunctional hybrid sponge via enzymatic cross-linking to accelerate infected burn wound healing》的研究论文，李兢思为第一作者。

图 1 文章发表的数字证书

图 2 IJBM期刊封面

图 3 该研究论文首页

International Journal of Biological Macromolecules (IJBM) is an established international journal of research into chemical and biological aspects of all natural macromolecules. It presents the latest findings of studies on the molecular structure and properties of proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids. These findings must be new and novel rather than a repeat of earlier or analogous published work. The scope includes biological activities and interactions, molecular associations, chemical and biological modifications, and functional properties. Papers on related model systems, structural conformational studies, theoretical developments and new analytical techniques are also welcome.

图 4 IJBM期刊的CiteScore及排名

图 5 IJBM期刊的主要信息

Abstract—Preparing sponge dressings with stable wet adhesion remains difficult in wound repair, especially in burn wounds with bleeding and large amounts of exudate. In this work, a multifunctional hybrid sponge dressing (DHGT+PHMB+TiO2NPs) with good wet adhesion was developed by combining biomimetic and enzymatic cross-linking reactions. The sponge dressing matrix (DHGT) was prepared by tyrosinase-catalyzed cross-linking of dopamine-modified hyaluronic acid (DOPA-HA) and gelatin. The multifunctional hybrid sponge dressing was obtained by loading polyhexamethylene biguanide (PHMB) and titanium dioxide nanoparticles (TiO2NPs) onto the DHGT matrix. The newly developed sponge dressing exhibited high mechanical properties, good wet adhesion, antibacterial activity, reactive oxygen species (ROS) scavenging, biocompatibility, and excellent hemostasis ability. In vivo studies showed that the multifunctional hybrid sponge dressing could significantly accelerate the healing of infected full-thickness burn wounds by inhibiting bacterial growth, accelerating skin tissue reepithelialization, collagen deposition, and angiogenesis, as well as regulating the expression of inflammatory factors and cytokines.

图 6 该研究论文的思路图

简言之，本研究基于贻贝启发的粘附和酪氨酸酶催化的交联反应，开发了一种促进烧伤感染性创面愈合的多功能复合海绵敷料。体外实验结果表明，所制备的海绵敷料具有良好的吸收伤口渗液的能力、优良的力学性能和活性氧清除能力；剪切和剥离实验表明，海绵敷料对各种不同的基质具有较强的粘附性；此外，海绵敷料具有广谱抗菌活性，能有效抑制大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的生长和繁殖。此外，海绵敷料具有较高的细胞相容性，能有效促进细胞的增殖和迁移，且不引起溶血。SD大鼠体内实验结果表明，海绵敷料具有良好的组织粘附性，可在出血部位形成网状屏障，明显减少肝出血。而且，海绵敷料可通过抑制细菌生长、加速皮肤组织上皮再生、胶原沉积和血管生成以及调节CD31、IL-10和TNF-α的表达来加速感染全层烧伤创面的愈合。本研究结果表明，所开发的多功能复合海绵敷料是用于治疗烧伤感染型创面的一种有前途的候选材料。

论文链接：https://doi.org/10.1016/j.ijbiomac.2022.12.024